Collins and his colleagues have definitively put to rest the notion that bone grafting in children with polyostotic fibrous dysplasia will be of any benefit in managing the deformities of long bones. When asked about this study, leading orthopedic surgeon Robert Stanton said, “I am grateful that Dr. On average, patients who experience resorption were about 10 years old at the time of surgery, and the patients with bone graft survival were older, or about 21 years old. Researchers believe that age at the time of surgery may explain why some patients experienced resorption, and others did not. Of the bone grafts that were resorbed, the grafts lasted an average of 10 years. Only 25% of the grafts survived and were incorporated into the bone long-term. 4% grafts were partially resorbed. Researchers found that 71% of the bone grafts were fully resorbed over time, meaning that the healthy transplant bone reverted back into fibrous dysplasia bone lesions. The study looked at many different types of bone graft procedures including autograft procedures (grafts using patient’s own bone), allograft procedures (grafts from another person, often called cadaver bone), procedures that used a combination of autograft and allograft bone, grafts that served a structural purpose (such as supporting rods), and grafts that served no structural purposes. The study, conducted at the National Institutes of Health, followed patients with polyostotic fibrous dysplasia over an average of 20 years. The study was funded in part by a grant from the Fibrous Dysplasia Foundation. Home Blog Foundation News Research News New Study Finds that Bone Grafts Are Likely to Resorb, Especially in Younger Patients New Study Finds that Bone Grafts Are Likely to Resorb, Especially in Younger PatientsĪ new study suggests that bone-grafting appears to have limited value in treating fibrous dysplasia and McCune-Albright syndrome.
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